DBCO-PEG alkyne is a bifunctional PEG reagent, which contains a DBCO moiety and an alkyne group for continuous click chemical reaction with two different azides. 苯并环辛炔基团(DBCO)具有热稳定性,并且在不存在催化剂的情况下,通过应变促进的点击反应对叠氮化物基团具有高比反应性。
中文名称:二苯并环辛炔-聚乙二醇-炔基
英文名称:DBCO-PEG-Alkyne,Alkyne-PEG-DBCO
分子量:1000,2000,3400,5000,10000,20000
DBCO (dibenzocyclooctene) is a cycloalkyne, which can react with azide through 1,3-dipolar cycloaddition promoted by strain in aqueous solution, which is a biorthogonal reaction, also known as copper free click reaction. 该反应具有选择性和生物相容性,使得互补试剂可以与功能丰富的生物系统形成共价键。Copper free click reaction is a powerful tool for biocoupling without catalyst. DBCO reagent has fast kinetics and stability in water buffer, and can be used to label azide modified biomolecules with high specificity and reactivity.
西安凯新生物科技有限公司温馨提示:凯新生物所有试剂均为科研用试剂,不用于人体。
Alkyne PEG is a kind of PEG linker, which contains three bonds that react with azide groups under mild conditions. 炔烃PEG应用于点击化学生物偶联、生物标记、化学生物学和抗体偶联物(ADC).There are several different alkyne containing functional groups, such as propargyl, DBCO (dibenzocycloctyl) and BCN (bicyclic [6.1.0] nonyl). PEG arms increase the hydrophilicity of these connectors.