Missouri recorded 12 fatalities, with deaths also recorded in Kansas, Arkansas, Oklahoma, Texas and Mississippi after tornadoes ripped apart homes. The massive weather system has also produced deadly dust storms, wildfires and hail the size of baseballs.
At least 34 people are reported to have died in powerful storms across the United States.
The number of fatalities increased after eight people died in a highway pile-up caused by a dust storm in Sherman County, Kansas on Friday. At least 50 vehicles were involved.
Car crashes also killed four people during a dust storm in Texas .
Authorities in Missouri say 12 people died after tornadoes struck the state.
Officials have also reported six deaths in Mississippi , some three fatalities in Arkansas , and a single death in Oklahoma , which has declared a state of emergency.
Around 108 million people remain under widespread wind, flash flooding and wildfire alerts in central and southern US states.
More than 282,000 households are without power in midwestern and southern states, according to the monitoring website PowerOutage.us.
Tornado warnings are in place in parts of Illinois, Missouri, Arkansas, Mississippi, Indiana, and Kentucky as a massive storm system moves across the country.
A video posted to Facebook showed storm debris in Kentwood, Louisiana and emergency responders.
Evacuations were ordered in some communities in Oklahoma as more than 130 fires were reported across the state.
Nearly 300 homes have been damaged or destroyed across some 266 square miles (689 square kilometers), according to governor Kevin Stitt.
In Butler County, Missouri, on the border with Arkansas, local coroner Jim Akers said the man and his wife were sleeping when a tornado struck there.
Rescuers were able to pull the woman from the debris - but could not save the man whose mobile home was ripped apart.
"It was unrecognisable as a home. Just a debris field," he said, describing the scene. "The floor was upside down. We were walking on walls."
Large vehicles were also pictured overturned across the state.
Arkansas governor Sarah Huckabee Sanders warned the recovery could take months after surveying damage from an EF3 tornado in Cave City, in the north of the state.
A storm ranked as EF3, on a scale of one to five, requires wind speeds of between 136-165mph (218-265kph).
"It's hard to look at this level of devastation and not be heartbroken," she said. "It's a whole other world when you see it up close and personal."
In Mississippi, governor Tate Reeves confirmed six deaths in three counties and said three more people were missing.
Hail the size of baseballs
Winds gusting up to 80mph (130kph) were predicted from the Canadian border to Texas, threatening blizzard conditions in colder northern areas and wildfire risk in warmer, drier places to the south.
Hail was also a hazard, some the size of baseballs were reported in Christian County, the US weather service said.
Fatal pile-ups during dust storms
In Texas, four people were killed in car crashes around the city of Amarillo caused by a dust storm on Friday, according to the state's public safety department.
One of the deaths happened after three lorries collided with four other vehicles in Palmer County, Bovina's fire chief Cesar Marquez said. Another occurred after a pile-up of an estimated 38 cars.
"It's the worst I've ever seen," public safety department sergeant Cindy Barkley said, calling the near-zero visibility a nightmare.
"We couldn't tell that they were all together until the dust kind of settled."
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Three deaths happened due to storm damage in Independence County, Arkansas on Friday night, with a further 29 people injured across eight different counties, authorities said.
The Storm Prediction Center at the National Weather Service (NWS) issued an update on Sunday, warning of a moderate risk of severe thunderstorms.
The warning covers an area from the extreme southeastern part of Mississippi, across much of Alabama, into western Georgia and the western Florida panhandle. The NWS also said there was the potential for deadly flash flooding.
密苏里州有12人因龙卷风摧毁家园而死亡,堪萨斯州、阿肯色州、俄克拉荷马州、德克萨斯州和密西西比州也报告了死亡情况。这一大规模天气系统还引发了致命的沙尘暴、野火和相当于棒球大小的冰雹。
据报道,在美国各地发生的强风暴中,至少有34人丧生。
在上周五堪萨斯州谢尔曼县发生的一场沙尘暴引发的公路连环车祸中,有8人丧生,随后死亡人数增加。至少有50辆车卷入其中。
在德克萨斯州的一场沙尘暴中,也发生了四起车祸,导致四人死亡。
密苏里州当局称,龙卷风袭击该州后,有12人死亡。
官员还报告称,密西西比州有6人死亡,阿肯色州有3人死亡,俄克拉荷马州有1人死亡,而俄克拉荷马州已经宣布进入紧急状态。
在美国中南部各州,大约有1.08亿人仍在面临大风、突发洪水和野火警报的广泛影响。
根据监控网站PowerOutage.us的报告,中西部和南部地区有超过282,000户家庭停电。
在美国中西部多个州,包括伊利诺伊州、密苏里州、阿肯色州、密西西比州、印第安纳州和肯塔基州的部分地区已发布龙卷风警报,一场大型风暴系统正在横扫全国。
Facebook上发布的一段视频展示了路易斯安那州肯特伍德市的风暴残骸以及紧急救援人员的情况。
俄克拉荷马州的一些社区已经下达了疏散令,因为该州各地报告了超过130起火灾。
根据州长凯文·斯特的报告,大约有266平方英里(689平方公里)的地区内有近300户住宅被毁或损坏。
在密苏里州巴特勒县,靠近阿肯色州边境的地方,当地验尸官吉姆·阿克斯(Jim Akers)表示,一名男子和他的妻子当时正在睡觉,突然遭遇了龙卷风的袭击。
救援人员成功将这名女性从残骸中救出,但未能救出那名活动房屋被撕裂的男性。
他描述了当时的情况:“那里已经无法辨认出是家了,只看到一片残骸。地板倒置,我们正走在墙上。”
照片中还显示,该州内有多辆大型车辆被掀翻。
阿肯色州州长莎拉·哈克比·桑德斯(Sarah Huckabee Sanders)在考察了该州北部卡夫城(Cave City)的EF3级龙卷风灾害后,警告称灾后恢复工作可能需要数月时间。
根据一至五级的等级划分,EF3级别的风暴需要风速介于136-165英里/小时(218-265公里/小时)之间。
她说:“面对如此规模的毁灭,很难不感到心碎。当你近距离亲身感受到时,这完全是另一个世界。”
密西西比州州长泰特·里夫斯(Tate Reeves)确认了三个县内六人死亡,并表示还有三人失踪。
冰雹的直径大小与棒球相似
从加拿大边境到德克萨斯州,预计将出现风速高达每小时80英里(130公里)的阵风,这将对较冷、较北的地区构成暴风雪威胁,同时对较暖、较干燥的南部地区构成野火风险。
美国气象局表示,在克里斯琴县也出现了冰雹,有的冰雹大小如棒球。
沙尘暴期间发生的致命车辆连环相撞事故
根据德克萨斯州公共安全部门的数据,周五的一场沙尘暴导致阿马里洛市周边发生汽车事故,造成4人死亡。
波维纳消防局长塞萨尔·马奎兹(Cesar Marquez)表示,其中一起事故发生在三辆卡车与波尔默县其他四辆车相撞之后。另一起事故则发生在大约38辆车连环相撞之后。
公共安全部门警官辛迪·巴克利(Cindy Barkley)表示:“这是我见过的最糟糕的情况”,她形容这种几乎为零的能见度为噩梦。
直到尘埃落定,我们才明白他们其实都在一起。
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据有关部门称,周五晚上,阿肯色州独立县因风暴受损导致三人死亡,另有29人在八个不同县区受伤。
美国国家气象局(NWS)的风暴预测中心在周日发布了一项更新,警告称存在中度强风暴风险。
该预警区域包括密西西比州的最东南部地区,以及大部分阿拉巴马州、佐治亚州西部和佛罗里达州西部半岛。美国国家气象局还指出,存在发生致命性突发洪水的可能。